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KMID : 0948320040040020147
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Konyang Medical Journal
2004 Volume.4 No. 2 p.147 ~ p.152
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The Age-specific Reference Ranges for Prostate-specific Antigen
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Oh Sei-Kwon
Chang Young-Seop
Song Ki-Hak
Cho Kun-Hyun
Kim Hong-Wook
Lee Jin-Moo
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Abstract
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Purpose: We intend to define age-specific ranges for serum prostate-specific antigen (serum PSA) and to investigate the relation between the age and serum PSA obtained from Konyang University Hospital visitors.
Materials and Methods: Between January 2000 and February 2004, we evaluated serum PSA of 3,805 men aged 20 to 89 years (111 aged 20 to 29 years, 535 aged 30 to 39 years, 869 aged 40 to 49 years, 904 aged 50 to 59 years, 871 aged 60 to 69 years, 409 aged 70 to 79 years, and 106 aged 80 to 89 years) using Microparticle Enzyme Immunoassay (MEIA, AxSYM kit, Abbott Co.) techniques. Statistical analysis was performed by simple linear regression analysis using SPSS.
Result: Average serum PSA of 3,805 men was 1.24 ng/ml. Mean value for serum PSA for men aged 20 to 29 years was 0.740.05 ng/ml; for 30 to 39 years, 0.830.32 ng/ml; for 40 to 49 years, 0.840.03 ng/ml; for 50 to 59 years, 1.040.03 ng/ml; for 60 to 69 years, 1.630.06 ng/ml; for 70 to 79 years, 2.150.10 ng/ml; for 80 to 89 years, 2.170.20 ng/ml, respectively. Age specific ranges for serum PSA for men aged 20 to 29 years was 1.40 ng/ml; for 30 to 39 years, 1.75 ng/ml; for 40 to 49 years, 2.06 ng/ml; for 50 to 59 years, 2.91 ng/ml; for 60 to 69 years, 5.29 ng/ml; for 70 to 79 years, 6.17 ng/ ml; for 80 to 89 years 6.36 ng/ml.
Conclusion: Based on linear regression analysis, serum PSA concentration was correlated with age (r = 0.327, p value 0.001). And serum PSA concentration was correlated with prostate volume (r = 0.593, p-value0.001). It is more appropriate to have age-specific reference ranges rather than depending on a single cutoff value irrespective of different age groups. Age-specific reference ranges for serum PSA would be attributed to increase the detection rate of localizing prostate cancer in younger ages, and to decrease the risk of missing prostate cancer in older ages.
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KEYWORD
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Age-specific reference range, Prostate-specific antigen
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